Orbitrap Technology for GC

Q Exactive™ GC hybrid quadrupole Orbitrap mass spectrometer

Q Exactive GC hybrid quadrupole Orbitrap mass spectrometer

The Thermo Scientific™ Q Exactive™ GC hybrid quadrupole Orbitrap mass spectrometer provides an unmatched combination of sensitivity, mass-accuracy and resolving power, helping answer today’s most challenging analytical questions.


The full MS scanning sensitivity combined with the selectivity achieved at resolutions of 50,000 and higher provides detection limits comparable to the best GC-triple quadrupoles while operating in an untargeted full MS scan mode. The included chemical ionization source provides soft ionization for pseudomolecular ion generation, and the analytical quadrupole and HCD cell allow for structural characterization experiments through MS/MS fragmentation. This world-class performance and comprehensive toolkit comes in a userfriendly bench-top design, with standard ease-of-use features including vent free source and column exchange.

Ion Source

Ion Source
  • Thermo Scientific™ ExtractaBrite™ Electron Ionization (EI) source
  • Ion source includes ion volume, repeller, source lenses, RF lens and dual filaments in all ionization modes, programmable from 50 °C to 350 °C
  • Chemical Ionization (CI) source for acquisition with Positive Ion Chemical Ionization (PCI) and Negative Ion Chemical Ionization (NCI)
  • Remove entire ion source or change to CI source in under 2 minutes without venting
  • Vent-free column exchange with new patented source plug
  • Combination EI/PCI/NCI ion volume can be used without need for source interchange 



MS Ion Optics

  • Advanced prefiltering and axial field bent flatapole ion guide reduces noise by preventing neutrals from entering the quadrupole



Quadrupole Mass Filter

  • Advanced Quadrupole Technology (AQT) featuring a segmented Thermo Scientific™ HyperQuad™ mass filter provides increased ion transmission and superior isolation window shape
  • Variable precursor ion isolation width selection from 0.4 Da to full mass range Figure





Orbitrap Mass Analyzer

  • Nitrogen-filled C-Trap
  • Highly efficient ion transfer to Orbitrap mass analyzer
  • Straight multipole collision cell for HCD
  • Low-noise image current preamplifier
  • 16-bit signal digitalization



Data Acquisition

  • Ultrafast real-time data acquisition and instrument control system
  • Fully automated tune and calibration via instrument control software
  • Automatic gain control



Performance Characteristics

Resolving Power: 100,000 @ m/z 272

Mass Range: 50 to 3,000 m/z

Scan Rate:* Up to 18 Hz at resolution setting of 12,500 @ m/z 272

Mass Accuracy:** Internal:  <1 ppm RMSExternal: <3 ppm RMS

Quantitative Dynamic Range*: >106

In-Spectrum Dynamic Range: >5000:1

Multiplexity: Up to 10 precursors/scan


* Under defined conditions

** Under conditions defined in 1 μL, 100 fg/μLoctafluoronaphthalene EI Full MS installationspecification

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Fax +41 43 260 95 36