LC 4000 Series Autosamplers

Autosamplers: AS-4050/4050i/4150/4250/4058


The LC-4000 Series autosamplers provide a range of options to suit any sample injection requirements, from the AS-4050 entry-level model, to the AS-4250 UHPLC model or the AS-4058 preparative scale autosampler.

The AS-4050 is a 60 sample autosampler for use with conventional HPLC with options for analytical and semi-preparative injection volumes. The AS-4150 and AS-4250 are high-capacity, high performance autosamplers designed for RHPLC (up to 70MPa)and UHPLC (up to 130MPa), respectively, with a minimum injection cycle-time of only 30 seconds. Peltier cooling is available for all autosamplers and light protection for photo- labile samples is available on the higher level models.


Pre-injection sample preparation is available on the high performance autosamplers with programmable options for sample dilution and pre-column derivitization.

AS-4050 60 sample HPLC autosampler
AS-4050 60 sample HPLC autosampler

The injection mode can be switched between full loop injection and partial loop injections


Up to 5 different washing solvents can be used to achieve excellent carry-over at less than 0.005%.


An optional degasser can be installed for degassing up to 5 flushing solvents.
The AS-4058 is the LC-4000 Series largest volume autosampler with injection volumes up to 5mL as standard (up to 10mL as an option). The AS-4058 is typically used in combination with either a PU-4087 or PU-4088 pump for preparative separations.


All LC-4000 series autosamplers share the same simple maintenance features, with consumable parts such as injection ports, rotor seals, and loops accessible from the front panel for easy replacement.

AS-4050 High capacity UHPLC autosampler
AS-4050 High capacity UHPLC autosampler

AS-4050/4150/4250/4058 flow diagram (loop injection)

Flow Diagram

Designed for easy maintenance



Simple replacement of syringe in AS-4050
Simple replacement of syringe in AS-4050

PAL System Autosamplers

Jasco LC-System as well as all other systems can be configured with the PAL System Autosampler and its own software.

PAL System

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Fax +41 43 260 95 36